相互作用
Carbamazepine + Dabrafenib
重症度: 重大
Carbamazepine and Dabrafenib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Carbamazepine can substantially lower dabrafenib exposure and reduce antitumor efficacy. Dabrafenib itself is an inducer, so effects on carbamazepine levels may also occur.
この相互作用をわかりやすく説明すると
Carbamazepine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Dabrafenib belongs to Oncology.
なぜ起こるのか
Induction of CYP3A4 and CYP2C8 increases dabrafenib metabolism.
対処法
Avoid combining and substitute a non-inducing anticonvulsant. If it is required, monitor tumor response and carbamazepine levels.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbamazepineとDabrafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbamazepineのその他の相互作用
Dabrafenibのその他の相互作用
よくある質問
Can I take Carbamazepine with Dabrafenib?
MediHelp rates the interaction as major. Carbamazepine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can substantially lower dabrafenib exposure and reduce antitumor efficacy. Dabrafenib itself is an inducer, so effects on carbamazepine levels may also occur.
How serious is the interaction between Carbamazepine and Dabrafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining and substitute a non-inducing anticonvulsant. If it is required, monitor tumor response and carbamazepine levels.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
