相互作用
Carbenoxolone + Furosemide
重症度: 重大
Carbenoxolone and Furosemide: major interaction.
最終更新日
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概要
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to furosemide-induced hypokalemia. It may also oppose diuretic and antihypertensive effects.
この相互作用をわかりやすく説明すると
Carbenoxolone and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Inhibition of 11-beta-hydroxysteroid dehydrogenase causes mineralocorticoid excess, additive with loop diuretic kaliuresis.
対処法
Monitor serum potassium and blood pressure closely and supplement potassium, or avoid the combination in patients with heart disease or on digoxin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbenoxoloneとFurosemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Furosemideのその他の相互作用
よくある質問
Can I take Carbenoxolone with Furosemide?
MediHelp rates the interaction as major. Carbenoxolone and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to furosemide-induced hypokalemia. It may also oppose diuretic and antihypertensive effects.
How serious is the interaction between Carbenoxolone and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure closely and supplement potassium, or avoid the combination in patients with heart disease or on digoxin.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Cephaloridine. The full list is on the Furosemide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
