相互作用
Cisplatin + Furosemide
重症度: 重大
Cisplatin and Furosemide: major interaction.
最終更新日
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概要
Both drugs can damage the cochlea, and loop diuretics given with cisplatin increase the risk of hearing loss and tinnitus, which may be permanent. Furosemide can also worsen cisplatin-related nephrotoxicity through volume depletion and electrolyte loss.
この相互作用をわかりやすく説明すると
Cisplatin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Furosemide belongs to Cardiovascular.
なぜ起こるのか
Additive ototoxicity affecting cochlear hair cells and the stria vascularis, plus additive renal and electrolyte effects.
対処法
Avoid routine concurrent use where possible and use furosemide only when needed for hydration-related volume overload. Obtain audiometry and monitor renal function, magnesium and potassium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisplatinとFurosemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Furosemideのその他の相互作用
Cisplatinのその他の相互作用
よくある質問
Can I take Cisplatin with Furosemide?
MediHelp rates the interaction as major. Cisplatin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the cochlea, and loop diuretics given with cisplatin increase the risk of hearing loss and tinnitus, which may be permanent. Furosemide can also worsen cisplatin-related nephrotoxicity through volume depletion and electrolyte loss.
How serious is the interaction between Cisplatin and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use where possible and use furosemide only when needed for hydration-related volume overload. Obtain audiometry and monitor renal function, magnesium and potassium.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
