相互作用
Cefalexin + Kanamycin
重症度: 中等度
Cefalexin and Kanamycin: moderate interaction.
最終更新日
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概要
Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
この相互作用をわかりやすく説明すると
Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Additive nephrotoxic potential, with reduced renal function leading to higher aminoglycoside accumulation and ototoxicity risk.
対処法
Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefalexinとKanamycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefalexinのその他の相互作用
よくある質問
Can I take Cefalexin with Kanamycin?
MediHelp rates the interaction as moderate. Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
How serious is the interaction between Cefalexin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
