相互作用
Cefpodoxime + Gentamicin
重症度: 中等度
Cefpodoxime and Gentamicin: moderate interaction.
最終更新日
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概要
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
この相互作用をわかりやすく説明すると
Cefpodoxime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
なぜ起こるのか
Possible additive renal tubular injury; cefpodoxime itself is rarely nephrotoxic.
対処法
Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefpodoximeとGentamicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefpodoximeのその他の相互作用
Gentamicinのその他の相互作用
よくある質問
Can I take Cefpodoxime with Gentamicin?
MediHelp rates the interaction as moderate. Cefpodoxime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
How serious is the interaction between Cefpodoxime and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
