相互作用
Amlodipine-hydrochlorothiazide-valsartan + Gentamicin
重症度: 重大
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin: major interaction.
最終更新日
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概要
Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
この相互作用をわかりやすく説明すると
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
なぜ起こるのか
Additive renal electrolyte wasting, with diuretic volume depletion and angiotensin blockade increasing susceptibility to aminoglycoside nephrotoxicity.
対処法
Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-hydrochlorothiazide-valsartanとGentamicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-hydrochlorothiazide-valsartanのその他の相互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 併用禁忌
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 重大
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 重大
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 重大
Gentamicinのその他の相互作用
よくある質問
Can I take Amlodipine-hydrochlorothiazide-valsartan with Gentamicin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
