相互作用
Chlorothiazide + Hydrochlorothiazide-losartan
重症度: 重大
Chlorothiazide and Hydrochlorothiazide-losartan: major interaction.
最終更新日
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概要
Using chlorothiazide with a hydrochlorothiazide-containing product duplicates thiazide therapy, increasing the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
この相互作用をわかりやすく説明すると
Chlorothiazide and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
なぜ起こるのか
Duplicate inhibition of the distal tubule sodium-chloride cotransporter giving additive diuresis and electrolyte loss.
対処法
Avoid combining two thiazides and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、ChlorothiazideとHydrochlorothiazide-losartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrochlorothiazide-losartanのその他の相互作用
Chlorothiazideのその他の相互作用
よくある質問
Can I take Chlorothiazide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Chlorothiazide and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using chlorothiazide with a hydrochlorothiazide-containing product duplicates thiazide therapy, increasing the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
