相互作用
Cholestyramine + Mycophenolic acid
重症度: 重大
Cholestyramine and Mycophenolic acid: major interaction.
最終更新日
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概要
Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
この相互作用をわかりやすく説明すると
Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Mycophenolic acid belongs to Miscellaneous.
なぜ起こるのか
Bile acid sequestrant binds mycophenolate glucuronide and MPA in the gut, preventing reabsorption.
対処法
Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CholestyramineとMycophenolic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mycophenolic acidのその他の相互作用
Cholestyramineのその他の相互作用
よくある質問
Can I take Cholestyramine with Mycophenolic acid?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
How serious is the interaction between Cholestyramine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Ganciclovir. The full list is on the Mycophenolic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
