相互作用
Clarithromycin + Lonafarnib
重症度: 併用禁忌
Clarithromycin and Lonafarnib: contraindicated interaction.
最終更新日
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概要
Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
この相互作用をわかりやすく説明すると
Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Lonafarnib belongs to Miscellaneous.
なぜ起こるのか
Clarithromycin inhibits CYP3A4, decreasing lonafarnib clearance.
対処法
Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとLonafarnibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Lonafarnibのその他の相互作用
よくある質問
Can I take Clarithromycin with Lonafarnib?
MediHelp rates the interaction as contraindicated. Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
How serious is the interaction between Clarithromycin and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
