相互作用
Clarithromycin + Selumetinib
重症度: 重大
Clarithromycin and Selumetinib: major interaction.
最終更新日
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概要
Clarithromycin may increase selumetinib exposure, which can intensify adverse effects such as gastrointestinal toxicity, rash, cardiomyopathy and ocular toxicity.
この相互作用をわかりやすく説明すると
Clarithromycin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Selumetinib belongs to Oncology.
なぜ起こるのか
Clarithromycin inhibits CYP3A4, reducing selumetinib metabolism.
対処法
Prefer a non-CYP3A4-inhibiting antibiotic. If necessary, reduce the selumetinib dose as per labeling and resume the prior dose after about 3 half-lives of clarithromycin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとSelumetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Selumetinibのその他の相互作用
よくある質問
Can I take Clarithromycin with Selumetinib?
MediHelp rates the interaction as major. Clarithromycin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may increase selumetinib exposure, which can intensify adverse effects such as gastrointestinal toxicity, rash, cardiomyopathy and ocular toxicity.
How serious is the interaction between Clarithromycin and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting antibiotic. If necessary, reduce the selumetinib dose as per labeling and resume the prior dose after about 3 half-lives of clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
