相互作用
Clopidogrel + Repaglinide
重症度: 重大
Clopidogrel and Repaglinide: major interaction.
最終更新日
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概要
Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.
この相互作用をわかりやすく説明すると
Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Repaglinide belongs to Endocrine.
なぜ起こるのか
Inhibition of CYP2C8-mediated repaglinide metabolism by clopidogrel's glucuronide metabolite.
対処法
Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClopidogrelとRepaglinideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clopidogrelのその他の相互作用
Repaglinideのその他の相互作用
よくある質問
Can I take Clopidogrel with Repaglinide?
MediHelp rates the interaction as major. Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.
How serious is the interaction between Clopidogrel and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
