相互作用
Deferasirox + Repaglinide
重症度: 重大
Deferasirox and Repaglinide: major interaction.
最終更新日
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概要
Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.
この相互作用をわかりやすく説明すると
Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Repaglinide belongs to Endocrine.
なぜ起こるのか
Deferasirox inhibits CYP2C8, a key pathway for repaglinide clearance.
対処法
Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DeferasiroxとRepaglinideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Repaglinideのその他の相互作用
Deferasiroxのその他の相互作用
よくある質問
Can I take Deferasirox with Repaglinide?
MediHelp rates the interaction as major. Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.
How serious is the interaction between Deferasirox and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
