相互作用
Cyclophosphamide + Dengue vaccine
重症度: 重大
Cyclophosphamide and Dengue vaccine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Cyclophosphamide suppresses immune function and may blunt the antibody response to the dengue vaccine, leaving the patient inadequately protected. The dengue vaccine is live attenuated, so vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
この相互作用をわかりやすく説明すると
Cyclophosphamide and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cytotoxic immunosuppression reduces vaccine immune response and impairs control of live attenuated virus replication.
対処法
Avoid giving the live dengue vaccine during cyclophosphamide therapy; vaccinate at least several weeks before starting treatment or after immune recovery, as advised by specialist guidance.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclophosphamideとDengue vaccineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclophosphamideのその他の相互作用
よくある質問
Can I take Cyclophosphamide with Dengue vaccine?
MediHelp rates the interaction as major. Cyclophosphamide and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclophosphamide suppresses immune function and may blunt the antibody response to the dengue vaccine, leaving the patient inadequately protected. The dengue vaccine is live attenuated, so vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
How serious is the interaction between Cyclophosphamide and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine during cyclophosphamide therapy; vaccinate at least several weeks before starting treatment or after immune recovery, as advised by specialist guidance.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
