相互作用
Cyclosporin + Tacrolimus
重症度: 併用禁忌
Cyclosporin and Tacrolimus: contraindicated interaction.
最終更新日
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概要
Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
この相互作用をわかりやすく説明すると
Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
なぜ起こるのか
Additive calcineurin inhibition and toxicity, with competition for CYP3A4 and P-glycoprotein altering exposure of either drug.
対処法
Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとTacrolimusの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Tacrolimusのその他の相互作用
よくある質問
Can I take Cyclosporin with Tacrolimus?
MediHelp rates the interaction as contraindicated. Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
How serious is the interaction between Cyclosporin and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
