相互作用
Dapagliflozin-metformin + Ethiodized oil
重症度: 重大
Dapagliflozin-metformin and Ethiodized oil: major interaction.
最終更新日
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概要
Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
この相互作用をわかりやすく説明すると
Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
対処法
Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dapagliflozin-metforminとEthiodized oilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dapagliflozin-metforminのその他の相互作用
よくある質問
Can I take Dapagliflozin-metformin with Ethiodized oil?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Ethiodized oil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
