相互作用
Dengue vaccine + Fludarabine
重症度: 重大
Dengue vaccine and Fludarabine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Dengue vaccine (Dengvaxia) is a live attenuated vaccine. Fludarabine-induced immunosuppression may blunt the immune response to it, and in a severely immunocompromised patient the live virus could cause vaccine-related disease.
この相互作用をわかりやすく説明すると
Dengue vaccine and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Fludarabine-induced lymphocyte depletion reduces the immune response to the vaccine and may allow uncontrolled replication of the live vaccine virus.
対処法
Do not give live dengue vaccine during fludarabine therapy or while the patient remains significantly immunosuppressed afterward; vaccinate once immune recovery is confirmed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dengue vaccineとFludarabineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Fludarabineのその他の相互作用
よくある質問
Can I take Dengue vaccine with Fludarabine?
MediHelp rates the interaction as major. Dengue vaccine and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine. Fludarabine-induced immunosuppression may blunt the immune response to it, and in a severely immunocompromised patient the live virus could cause vaccine-related disease.
How serious is the interaction between Dengue vaccine and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live dengue vaccine during fludarabine therapy or while the patient remains significantly immunosuppressed afterward; vaccinate once immune recovery is confirmed.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
