相互作用
Diflunisal + Ketorolac intranasal
重症度: 併用禁忌
Diflunisal and Ketorolac intranasal: contraindicated interaction.
最終更新日
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概要
Ketorolac labeling contraindicates concurrent NSAIDs, including aspirin-type salicylates such as diflunisal. The combination adds gastrointestinal bleeding, ulcer and renal injury risk without added analgesic benefit.
この相互作用をわかりやすく説明すると
Diflunisal and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
対処法
Do not use together. Use a single NSAID at a time and allow washout before switching.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DiflunisalとKetorolac intranasalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Diflunisalのその他の相互作用
よくある質問
Can I take Diflunisal with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Diflunisal and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac labeling contraindicates concurrent NSAIDs, including aspirin-type salicylates such as diflunisal. The combination adds gastrointestinal bleeding, ulcer and renal injury risk without added analgesic benefit.
How serious is the interaction between Diflunisal and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use a single NSAID at a time and allow washout before switching.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Acemetacin, Acetazolamide. The full list is on the Diflunisal page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
