相互作用
Dihydroergotamine intranasal + Miconazole
重症度: 重大
Dihydroergotamine intranasal and Miconazole: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Intranasal dihydroergotamine is still metabolized by CYP3A4, so inhibitors of this enzyme can increase systemic ergot exposure and the risk of vasospastic ischemia. Miconazole can inhibit CYP3A4 after systemic absorption, and ergotism can be severe.
この相互作用をわかりやすく説明すると
Dihydroergotamine intranasal and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Miconazole inhibits CYP3A4-mediated metabolism of dihydroergotamine, increasing its systemic concentrations.
対処法
Avoid the combination where possible and select a non-interacting antifungal or migraine therapy. If unavoidable, monitor for signs of peripheral ischemia such as cold, numb or painful limbs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dihydroergotamine intranasalとMiconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Miconazoleのその他の相互作用
よくある質問
Can I take Dihydroergotamine intranasal with Miconazole?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal dihydroergotamine is still metabolized by CYP3A4, so inhibitors of this enzyme can increase systemic ergot exposure and the risk of vasospastic ischemia. Miconazole can inhibit CYP3A4 after systemic absorption, and ergotism can be severe.
How serious is the interaction between Dihydroergotamine intranasal and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and select a non-interacting antifungal or migraine therapy. If unavoidable, monitor for signs of peripheral ischemia such as cold, numb or painful limbs.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine, Ergotamine. The full list is on the Miconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
