医薬品リファレンス
Miconazole
Miconazole is a medicine in the class anti fungals. It is used for oropharyngeal candidiasis.
- 薬効分類: Anti Fungals
- 効能・効果: oropharyngeal candidiasis
最終更新日 出典: US FDA label, UK SmPC, Base de donnees publique des medicaments (France), ANSM Base de donnees publique des medicaments (RCP, French)
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Fungals
- 一般的な剤形
- クリーム剤, 散剤, ゲル剤, 吸入器, 軟膏剤, 溶液
- 一般的な規格
- 2 g/100 g, 2%, 20 mg/g
- 既知の相互作用
- 50 (重大: 12 · 中等度: 24 · 軽度: 14)
- 商品名
- 232
- 国・市場
- 5
何に使われるか
作用のしくみ
Azole antifungal agent; inhibits enzyme cytochrome P450 14-alpha-demethylase resulting in ergosterol synthesis inhibition
成人の通常用量（添付文書の要約）
Oropharyngeal Candidiasis: Apply 50 mg buccal tab to gum region qDay for 14 consecutive days
妊娠と授乳
- 妊娠
- Unknown Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush).
- 授乳
- Safe No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
報告されている副作用
- Irritation
- Diarrhea
- Nausea
- Allergic contact dermatitis
- Burning
禁忌
- Hypersensitivity to drug, milk protein concentrate, or other excipients
注意が必要な方
- Miconazole is systemically absorbed and inhibits CYP2C9 and CYP3A4, prolonging the effect of warfarin; bleeding events, some fatal, have been reported with oral gel. Monitor the anticoagulant effect carefully if coumarin anticoagulants are used concomitantly.
- Choking risk in infants and young children (4 months to 2 years): do not apply the gel to the back of the throat, divide each dose into small portions and observe the patient. Do not apply it to a nipple for infant administration.
- Severe hypersensitivity reactions including anaphylaxis and angioedema have been reported; stop treatment if hypersensitivity or irritation occurs.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (50)
- Cabazitaxel + Miconazole Major
- Dihydroergotamine + Miconazole Major
- Dihydroergotamine intranasal + Miconazole Major
- Ergotamine + Miconazole Major
- Glyburide + Miconazole Major
- Lovastatin + Miconazole Major
- Methadone + Miconazole Major
- Miconazole + Pimozide Major
- Miconazole + Ribociclib Major
- Miconazole + Simvastatin Major
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Miconazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Miconazole used for?
Miconazole is a medicine in the class anti fungals. It is used for Oropharyngeal candidiasis, Tinea, Vulvovaginal candidiasis.
What side effects have been reported with Miconazole?
Irritation, Diarrhea, Nausea, Allergic contact dermatitis, Burning.
Can Miconazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Vaginal and skin forms: little is absorbed; topical azoles are preferred for thrush in pregnancy. Oral gel and buccal tablets are more absorbed; the buccal label warns of possible fetal harm from animal data, so avoid them if possible (nystatin is an option for mouth thrush). Breastfeeding: Safe. No data for buccal tablets. Poorly absorbed from skin, vagina and gut, so unlikely to affect the infant (LactMed), including when used on the nipples; remove excess before feeds and prefer creams or gels to ointments on the breast.
What does Miconazole interact with?
MediHelp lists 50 known interactions for Miconazole. Major: 12 · Moderate: 24 · Minor: 14. The most serious include Cabazitaxel, Dihydroergotamine, Dihydroergotamine intranasal.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
