相互作用
Diltiazem + Ivabradine
重症度: 併用禁忌
Diltiazem and Ivabradine: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Diltiazem increases ivabradine exposure and also lowers heart rate itself. The combination can cause marked bradycardia, conduction block and related symptoms such as dizziness or syncope.
この相互作用をわかりやすく説明すると
Diltiazem and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diltiazem belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
なぜ起こるのか
Moderate CYP3A4 inhibition raises ivabradine concentrations, with additive sinus node slowing from both drugs.
対処法
Avoid the combination; labeling advises against ivabradine with diltiazem or verapamil. Choose an alternative antianginal or heart failure strategy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DiltiazemとIvabradineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Diltiazemのその他の相互作用
Ivabradineのその他の相互作用
よくある質問
Can I take Diltiazem with Ivabradine?
MediHelp rates the interaction as contraindicated. Diltiazem and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diltiazem increases ivabradine exposure and also lowers heart rate itself. The combination can cause marked bradycardia, conduction block and related symptoms such as dizziness or syncope.
How serious is the interaction between Diltiazem and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against ivabradine with diltiazem or verapamil. Choose an alternative antianginal or heart failure strategy.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Diltiazem page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
