相互作用
Conivaptan + Ivabradine
重症度: 併用禁忌
Conivaptan and Ivabradine: contraindicated interaction.
最終更新日
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概要
Conivaptan is a strong CYP3A4 inhibitor and is expected to raise ivabradine concentrations considerably. Excess ivabradine effect may produce marked bradycardia and conduction disturbances.
この相互作用をわかりやすく説明すると
Conivaptan and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Conivaptan inhibits CYP3A4, reducing ivabradine clearance.
対処法
Do not combine; if conivaptan is required, hold ivabradine and consider alternatives for heart rate control.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ConivaptanとIvabradineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ivabradineのその他の相互作用
よくある質問
Can I take Conivaptan with Ivabradine?
MediHelp rates the interaction as contraindicated. Conivaptan and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a strong CYP3A4 inhibitor and is expected to raise ivabradine concentrations considerably. Excess ivabradine effect may produce marked bradycardia and conduction disturbances.
How serious is the interaction between Conivaptan and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; if conivaptan is required, hold ivabradine and consider alternatives for heart rate control.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
