相互作用
Dipyridamole + Vorapaxar
重症度: 重大
Dipyridamole and Vorapaxar: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Vorapaxar is a PAR-1 antagonist with antiplatelet action and carries a labeled bleeding risk. Combining it with dipyridamole, another antiplatelet agent, increases the likelihood of bleeding, including serious bleeding.
この相互作用をわかりやすく説明すると
Dipyridamole and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive inhibition of platelet function through different pathways (PAR-1 antagonism and adenosine reuptake/phosphodiesterase inhibition).
対処法
Avoid the combination where possible; if used, monitor closely for bleeding and reassess the need for each antiplatelet agent regularly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DipyridamoleとVorapaxarの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Dipyridamoleのその他の相互作用
よくある質問
Can I take Dipyridamole with Vorapaxar?
MediHelp rates the interaction as major. Dipyridamole and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 antagonist with antiplatelet action and carries a labeled bleeding risk. Combining it with dipyridamole, another antiplatelet agent, increases the likelihood of bleeding, including serious bleeding.
How serious is the interaction between Dipyridamole and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor closely for bleeding and reassess the need for each antiplatelet agent regularly.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
