相互作用
Dipyridamole + Venetoclax
重症度: 重大
Dipyridamole and Venetoclax: major interaction.
最終更新日
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概要
Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.
この相互作用をわかりやすく説明すると
Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dipyridamole belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
なぜ起こるのか
Dipyridamole inhibits P-glycoprotein efflux of venetoclax, increasing its systemic exposure.
対処法
Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DipyridamoleとVenetoclaxの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dipyridamoleのその他の相互作用
Venetoclaxのその他の相互作用
よくある質問
Can I take Dipyridamole with Venetoclax?
MediHelp rates the interaction as major. Dipyridamole and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole inhibits P-glycoprotein, which may increase venetoclax exposure and the risk of neutropenia and tumor lysis syndrome.
How serious is the interaction between Dipyridamole and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% as per labeling and monitor blood counts and tumor lysis parameters.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
