相互作用
Doxorubicin + Trastuzumab deruxtecan
重症度: 重大
Doxorubicin and Trastuzumab deruxtecan: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is greatest when they are given with or soon after anthracyclines such as doxorubicin. Both agents have cardiotoxic potential, so the combined risk of cardiomyopathy and heart failure is increased.
この相互作用をわかりやすく説明すると
Doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity through anthracycline-induced myocardial injury and HER2 pathway inhibition impairing cardiomyocyte repair.
対処法
Avoid concurrent anthracycline use where possible and consider the cumulative anthracycline dose and washout interval. If combined, assess LVEF before and regularly during treatment and monitor for heart failure symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DoxorubicinとTrastuzumab deruxtecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Doxorubicinのその他の相互作用
Trastuzumab deruxtecanのその他の相互作用
よくある質問
Can I take Doxorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is greatest when they are given with or soon after anthracyclines such as doxorubicin. Both agents have cardiotoxic potential, so the combined risk of cardiomyopathy and heart failure is increased.
How serious is the interaction between Doxorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent anthracycline use where possible and consider the cumulative anthracycline dose and washout interval. If combined, assess LVEF before and regularly during treatment and monitor for heart failure symptoms.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
