相互作用
Daunorubicin + Trastuzumab deruxtecan
重症度: 重大
Daunorubicin and Trastuzumab deruxtecan: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
この相互作用をわかりやすく説明すると
Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity from anthracycline myocardial injury and HER2 pathway inhibition in cardiomyocytes.
対処法
Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DaunorubicinとTrastuzumab deruxtecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Daunorubicinのその他の相互作用
Trastuzumab deruxtecanのその他の相互作用
よくある質問
Can I take Daunorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
How serious is the interaction between Daunorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
