相互作用
Doxorubicin + Trastuzumab
重症度: 重大
Doxorubicin and Trastuzumab: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.
この相互作用をわかりやすく説明すると
Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity: anthracycline myocyte injury combined with inhibition of HER2-mediated cardioprotective signaling.
対処法
Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DoxorubicinとTrastuzumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Doxorubicinのその他の相互作用
Trastuzumabのその他の相互作用
よくある質問
Can I take Doxorubicin with Trastuzumab?
MediHelp rates the interaction as major. Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.
How serious is the interaction between Doxorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
