相互作用
Liposomal doxorubicin + Trastuzumab
重症度: 重大
Liposomal doxorubicin and Trastuzumab: major interaction.
最終更新日
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概要
Trastuzumab can cause cardiomyopathy and left ventricular dysfunction, and the risk is markedly higher when it follows or is combined with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin, but additive cardiac injury remains a concern.
この相互作用をわかりやすく説明すると
Liposomal doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Liposomal doxorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity: anthracycline myocyte injury combined with HER2 pathway inhibition impairing cardiomyocyte repair.
対処法
Assess LVEF before and periodically during therapy, and avoid concurrent use outside carefully monitored settings. Hold trastuzumab or stop the anthracycline if LVEF falls significantly or heart failure symptoms appear.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Liposomal doxorubicinとTrastuzumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Liposomal doxorubicinのその他の相互作用
Trastuzumabのその他の相互作用
よくある質問
Can I take Liposomal doxorubicin with Trastuzumab?
MediHelp rates the interaction as major. Liposomal doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab can cause cardiomyopathy and left ventricular dysfunction, and the risk is markedly higher when it follows or is combined with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin, but additive cardiac injury remains a concern.
How serious is the interaction between Liposomal doxorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess LVEF before and periodically during therapy, and avoid concurrent use outside carefully monitored settings. Hold trastuzumab or stop the anthracycline if LVEF falls significantly or heart failure symptoms appear.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
