相互作用
Droperidol + Sotalol
重症度: 併用禁忌
Droperidol and Sotalol: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and sudden cardiac death. Droperidol carries a boxed warning for QT prolongation, and sotalol itself has a high intrinsic proarrhythmic risk.
この相互作用をわかりやすく説明すると
Droperidol and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive blockade of cardiac potassium channels (hERG/IKr) causing delayed repolarization and QT prolongation.
対処法
Avoid the combination; choose a non-QT-prolonging antiemetic or sedative such as ondansetron alternatives with lower risk only after ECG assessment. If unavoidable, use continuous ECG monitoring and correct potassium and magnesium first.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DroperidolとSotalolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sotalolのその他の相互作用
よくある質問
Can I take Droperidol with Sotalol?
MediHelp rates the interaction as contraindicated. Droperidol and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and sudden cardiac death. Droperidol carries a boxed warning for QT prolongation, and sotalol itself has a high intrinsic proarrhythmic risk.
How serious is the interaction between Droperidol and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-QT-prolonging antiemetic or sedative such as ondansetron alternatives with lower risk only after ECG assessment. If unavoidable, use continuous ECG monitoring and correct potassium and magnesium first.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
