相互作用
Dofetilide + Sotalol
重症度: 併用禁忌
Dofetilide and Sotalol: contraindicated interaction.
最終更新日
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概要
Both are class III antiarrhythmics that block cardiac potassium channels and prolong the QT interval. Together they markedly increase the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Dofetilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
なぜ起こるのか
Additive blockade of the delayed rectifier potassium current causing QT prolongation.
対処法
Do not use together; allow adequate washout of one agent before starting the other with ECG monitoring in a supervised setting.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DofetilideとSotalolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sotalolのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Dofetilide with Sotalol?
MediHelp rates the interaction as contraindicated. Dofetilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class III antiarrhythmics that block cardiac potassium channels and prolong the QT interval. Together they markedly increase the risk of torsades de pointes.
How serious is the interaction between Dofetilide and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow adequate washout of one agent before starting the other with ECG monitoring in a supervised setting.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
