相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lamivudine
重症度: 併用禁忌
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine: contraindicated interaction.
最終更新日
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概要
This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Therapeutic duplication: lamivudine and emtricitabine are both cytidine analogues sharing the same target and resistance pathway.
対処法
Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとLamivudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lamivudineのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lamivudine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product already contains emtricitabine, which is closely related to lamivudine, so adding lamivudine duplicates the same cytosine analogue activity. This provides no added benefit, gives overlapping resistance selection, and raises the toxicity burden.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lamivudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; the single-tablet regimen is complete and should not be given with other antiretrovirals. Stop lamivudine if the regimen is used.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Atidarsagene autotemcel, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
