相互作用
Lamivudine + Lovotibeglogene autotemcel
重症度: 重大
Lamivudine and Lovotibeglogene autotemcel: major interaction.
最終更新日
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概要
Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cells because they inhibit lentiviral vector transduction. This may result in a failed or inadequate product.
この相互作用をわかりやすく説明すると
Lamivudine and Lovotibeglogene autotemcel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Nucleoside reverse transcriptase inhibitors block reverse transcription of the lentiviral vector, impairing transduction of harvested cells.
対処法
Stop lamivudine at least one month before mobilization and until all apheresis cycles are done. Involve an HIV specialist in managing the interruption.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LamivudineとLovotibeglogene autotemcelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lamivudineのその他の相互作用
よくある質問
Can I take Lamivudine with Lovotibeglogene autotemcel?
MediHelp rates the interaction as major. Lamivudine and Lovotibeglogene autotemcel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cells because they inhibit lentiviral vector transduction. This may result in a failed or inadequate product.
How serious is the interaction between Lamivudine and Lovotibeglogene autotemcel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lamivudine at least one month before mobilization and until all apheresis cycles are done. Involve an HIV specialist in managing the interruption.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
