相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Valacyclovir
重症度: 中等度
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir: moderate interaction.
最終更新日
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概要
Acyclovir, formed from valacyclovir, emtricitabine and tenofovir are all cleared by renal filtration and tubular secretion. Co-administration can raise levels of each and tenofovir adds nephrotoxic potential.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Competition for renal tubular secretion plus additive nephrotoxicity, and cobicistat further reduces tubular creatinine secretion.
対処法
Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the valacyclovir dose to renal function and stop the combination if renal function worsens.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとValacyclovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Valacyclovirのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Valacyclovir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acyclovir, formed from valacyclovir, emtricitabine and tenofovir are all cleared by renal filtration and tubular secretion. Co-administration can raise levels of each and tenofovir adds nephrotoxic potential.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinalysis regularly. Adjust the valacyclovir dose to renal function and stop the combination if renal function worsens.
What other medicines interact with Valacyclovir?
MediHelp also lists interactions of Valacyclovir with, for example, Talimogene laherparepvec, Bacitracin, Cilastatin-imipenem. The full list is on the Valacyclovir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
