相互作用
Mycophenolic acid + Valacyclovir
重症度: 中等度
Mycophenolic acid and Valacyclovir: moderate interaction.
最終更新日
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概要
Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
この相互作用をわかりやすく説明すると
Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolic acid belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.
なぜ起こるのか
Competition between acyclovir and MPA glucuronide for renal tubular secretion.
対処法
Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Mycophenolic acidとValacyclovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mycophenolic acidのその他の相互作用
Valacyclovirのその他の相互作用
よくある質問
Can I take Mycophenolic acid with Valacyclovir?
MediHelp rates the interaction as moderate. Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
How serious is the interaction between Mycophenolic acid and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
