相互作用
Empagliflozin-metformin + Trilaciclib
重症度: 重大
Empagliflozin-metformin and Trilaciclib: major interaction.
最終更新日
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概要
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
この相互作用をわかりやすく説明すると
Empagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Empagliflozin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
なぜ起こるのか
Inhibition of renal OCT2 and MATE1/MATE2-K transporters reduces metformin elimination.
対処法
Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Empagliflozin-metforminとTrilaciclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Empagliflozin-metforminのその他の相互作用
Trilaciclibのその他の相互作用
よくある質問
Can I take Empagliflozin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Empagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Empagliflozin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
