相互作用
Cisplatin + Trilaciclib
重症度: 重大
Cisplatin and Trilaciclib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
この相互作用をわかりやすく説明すると
Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Trilaciclib belongs to Oncology.
なぜ起こるのか
Inhibition of OCT2, MATE1 and MATE2-K by trilaciclib changes renal tubular transport of cisplatin.
対処法
Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisplatinとTrilaciclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cisplatinのその他の相互作用
Trilaciclibのその他の相互作用
よくある質問
Can I take Cisplatin with Trilaciclib?
MediHelp rates the interaction as major. Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
How serious is the interaction between Cisplatin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
