相互作用
Epinephrine + Tranylcypromine
重症度: 併用禁忌
Epinephrine and Tranylcypromine: contraindicated interaction.
最終更新日
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概要
Epinephrine is partly cleared by MAO and COMT, and tranylcypromine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
この相互作用をわかりやすく説明すると
Epinephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Epinephrine belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
なぜ起こるのか
MAO inhibition potentiating sympathomimetic effects
対処法
Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EpinephrineとTranylcypromineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tranylcypromineのその他の相互作用
Epinephrineのその他の相互作用
よくある質問
Can I take Epinephrine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Epinephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Epinephrine is partly cleared by MAO and COMT, and tranylcypromine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
How serious is the interaction between Epinephrine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
