相互作用
Estradiol + Fezolinetant
重症度: 併用禁忌
Estradiol and Fezolinetant: contraindicated interaction.
最終更新日
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概要
Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.
この相互作用をわかりやすく説明すると
Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Estradiol belongs to Endocrine; Fezolinetant belongs to Endocrine.
なぜ起こるのか
Estrogens inhibit CYP1A2, the main enzyme metabolizing fezolinetant.
対処法
Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、EstradiolとFezolinetantの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Estradiolのその他の相互作用
Fezolinetantのその他の相互作用
よくある質問
Can I take Estradiol with Fezolinetant?
MediHelp rates the interaction as contraindicated. Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.
How serious is the interaction between Estradiol and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
