Drug interactions
Estradiol + Fezolinetant
Severity: Contraindicated
Estradiol and Fezolinetant: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.
What this interaction means in plain words
Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Estradiol belongs to Endocrine; Fezolinetant belongs to Endocrine.
Why it happens
Estrogens inhibit CYP1A2, the main enzyme metabolizing fezolinetant.
What to do
Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
- Estradiol + Fosphenytoin Major
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
Frequently asked questions
Can I take Estradiol with Fezolinetant?
MediHelp rates the interaction as contraindicated. Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.
How serious is the interaction between Estradiol and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Estradiol page.
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