相互作用
Ethambutol + Febuxostat
重症度: 中等度
Ethambutol and Febuxostat: moderate interaction.
最終更新日
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概要
Ethambutol reduces renal urate excretion and can cause hyperuricemia or gout flares, which opposes febuxostat's urate-lowering effect. Urate control may be worse than expected on the combination.
この相互作用をわかりやすく説明すると
Ethambutol and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethambutol belongs to Anti Bacterial; Febuxostat belongs to Genitourinary.
なぜ起こるのか
Ethambutol decreases renal tubular urate excretion, producing pharmacodynamic antagonism of febuxostat.
対処法
Monitor serum uric acid and gout symptoms during ethambutol therapy and titrate febuxostat as needed. Provide flare prophylaxis if appropriate.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EthambutolとFebuxostatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Febuxostatのその他の相互作用
Ethambutolのその他の相互作用
よくある質問
Can I take Ethambutol with Febuxostat?
MediHelp rates the interaction as moderate. Ethambutol and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can cause hyperuricemia or gout flares, which opposes febuxostat's urate-lowering effect. Urate control may be worse than expected on the combination.
How serious is the interaction between Ethambutol and Febuxostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol therapy and titrate febuxostat as needed. Provide flare prophylaxis if appropriate.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Azathioprine, Mercaptopurine, Didanosine. The full list is on the Febuxostat page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
