相互作用
Azathioprine + Febuxostat
重症度: 併用禁忌
Azathioprine and Febuxostat: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
この相互作用をわかりやすく説明すると
Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Febuxostat belongs to Genitourinary.
なぜ起こるのか
Febuxostat inhibits xanthine oxidase, which is needed to inactivate 6-mercaptopurine, leading to accumulation of active thiopurine metabolites.
対処法
Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、AzathioprineとFebuxostatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Febuxostat (Uloric) Prescribing Information - Drug Interactions — FDA Label
- Adenuric (febuxostat) Summary of Product Characteristics — EMA SmPC
Febuxostatのその他の相互作用
Azathioprineのその他の相互作用
- Adenovirus types 4 and 7 live + Azathioprine 併用禁忌
- Azathioprine + Bcg vaccine live 併用禁忌
- Azathioprine + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Azathioprine + Measles mumps and rubella vaccine 併用禁忌
- Azathioprine + Measles mumps and rubella vaccine live 併用禁忌
- Azathioprine + Measles mumps rubella and varicella vaccine live 併用禁忌
よくある質問
Can I take Azathioprine with Febuxostat?
MediHelp rates the interaction as contraindicated. Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
How serious is the interaction between Azathioprine and Febuxostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Mercaptopurine, Didanosine, Apalutamide. The full list is on the Febuxostat page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
