相互作用
Etrasimod + Pemetrexed
重症度: 重大
Etrasimod and Pemetrexed: major interaction.
最終更新日
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概要
Etrasimod lowers circulating lymphocytes, and pemetrexed causes myelosuppression, so the two together may increase susceptibility to infection. The combination has not been formally studied.
この相互作用をわかりやすく説明すると
Etrasimod and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Pemetrexed belongs to Oncology.
なぜ起こるのか
Additive immunosuppression from lymphocyte sequestration by etrasimod and bone marrow suppression by pemetrexed.
対処法
Avoid combining where possible, and allow for the lingering effect of etrasimod after it is stopped. If used together, monitor blood counts and watch for infection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EtrasimodとPemetrexedの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pemetrexedのその他の相互作用
Etrasimodのその他の相互作用
よくある質問
Can I take Etrasimod with Pemetrexed?
MediHelp rates the interaction as major. Etrasimod and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and pemetrexed causes myelosuppression, so the two together may increase susceptibility to infection. The combination has not been formally studied.
How serious is the interaction between Etrasimod and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and allow for the lingering effect of etrasimod after it is stopped. If used together, monitor blood counts and watch for infection.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
