相互作用
Fesoterodine + Tolterodine
重症度: 重大
Fesoterodine and Tolterodine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Fesoterodine is a prodrug of 5-hydroxymethyl tolterodine, which is the main active metabolite of tolterodine. Taking both gives duplicate antimuscarinic therapy and no added benefit. Anticholinergic adverse effects such as dry mouth, constipation, urinary retention and QT effects become more likely.
この相互作用をわかりやすく説明すると
Fesoterodine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fesoterodine belongs to Genitourinary; Tolterodine belongs to Genitourinary.
なぜ起こるのか
Therapeutic duplication, because both drugs yield the same active antimuscarinic metabolite.
対処法
Do not use the two together. Choose one agent and titrate it, or switch to another class such as a beta-3 agonist if the response is inadequate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FesoterodineとTolterodineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Tolterodineのその他の相互作用
Fesoterodineのその他の相互作用
よくある質問
Can I take Fesoterodine with Tolterodine?
MediHelp rates the interaction as major. Fesoterodine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fesoterodine is a prodrug of 5-hydroxymethyl tolterodine, which is the main active metabolite of tolterodine. Taking both gives duplicate antimuscarinic therapy and no added benefit. Anticholinergic adverse effects such as dry mouth, constipation, urinary retention and QT effects become more likely.
How serious is the interaction between Fesoterodine and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. Choose one agent and titrate it, or switch to another class such as a beta-3 agonist if the response is inadequate.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
