相互作用
Dronedarone + Tolterodine
重症度: 重大
Dronedarone and Tolterodine: major interaction.
最終更新日
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概要
Dronedarone is a moderate CYP3A4 inhibitor and a CYP2D6 inhibitor, so it can raise tolterodine exposure. Tolterodine and dronedarone can each prolong the QT interval, so higher tolterodine levels may increase arrhythmia risk. Anticholinergic adverse effects are also more likely.
この相互作用をわかりやすく説明すると
Dronedarone and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Tolterodine belongs to Genitourinary.
なぜ起こるのか
Dronedarone inhibits CYP3A4 and CYP2D6 metabolism of tolterodine, with additive QT effects.
対処法
Avoid the combination if possible, or use the lowest tolterodine dose and obtain an ECG. Correct potassium and magnesium and watch for palpitations or syncope.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DronedaroneとTolterodineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tolterodineのその他の相互作用
Dronedaroneのその他の相互作用
よくある質問
Can I take Dronedarone with Tolterodine?
MediHelp rates the interaction as major. Dronedarone and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone is a moderate CYP3A4 inhibitor and a CYP2D6 inhibitor, so it can raise tolterodine exposure. Tolterodine and dronedarone can each prolong the QT interval, so higher tolterodine levels may increase arrhythmia risk. Anticholinergic adverse effects are also more likely.
How serious is the interaction between Dronedarone and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use the lowest tolterodine dose and obtain an ECG. Correct potassium and magnesium and watch for palpitations or syncope.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
