相互作用
Flecainide + Ritonavir
重症度: 併用禁忌
Flecainide and Ritonavir: contraindicated interaction.
最終更新日
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概要
Ritonavir can markedly raise flecainide plasma concentrations. Flecainide has a narrow therapeutic index, so higher exposure raises the risk of conduction block, ventricular proarrhythmia and other serious cardiac toxicity.
この相互作用をわかりやすく説明すると
Flecainide and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir inhibits CYP2D6 (and CYP3A4), reducing the metabolic clearance of flecainide.
対処法
Avoid the combination; labeling for ritonavir contraindicates it. Choose an alternative antiarrhythmic or antiretroviral regimen.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FlecainideとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Flecainideのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Flecainide with Ritonavir?
MediHelp rates the interaction as contraindicated. Flecainide and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir can markedly raise flecainide plasma concentrations. Flecainide has a narrow therapeutic index, so higher exposure raises the risk of conduction block, ventricular proarrhythmia and other serious cardiac toxicity.
How serious is the interaction between Flecainide and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for ritonavir contraindicates it. Choose an alternative antiarrhythmic or antiretroviral regimen.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
