相互作用
Dronedarone + Ritonavir
重症度: 併用禁忌
Dronedarone and Ritonavir: contraindicated interaction.
最終更新日
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概要
Ritonavir is a potent CYP3A4 inhibitor and markedly raises dronedarone levels, increasing the risk of QT prolongation and torsades de pointes. Dronedarone may also modestly raise ritonavir exposure through P-glycoprotein inhibition.
この相互作用をわかりやすく説明すると
Dronedarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
なぜ起こるのか
Potent CYP3A4 inhibition by ritonavir reduces dronedarone clearance, with additional P-glycoprotein inhibition by dronedarone.
対処法
Do not coadminister; select an alternative antiarrhythmic or antiretroviral regimen.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、DronedaroneとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Dronedarone with Ritonavir?
MediHelp rates the interaction as contraindicated. Dronedarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a potent CYP3A4 inhibitor and markedly raises dronedarone levels, increasing the risk of QT prolongation and torsades de pointes. Dronedarone may also modestly raise ritonavir exposure through P-glycoprotein inhibition.
How serious is the interaction between Dronedarone and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select an alternative antiarrhythmic or antiretroviral regimen.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
