相互作用
Fluphenazine + Pimozide
重症度: 併用禁忌
Fluphenazine and Pimozide: contraindicated interaction.
最終更新日
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概要
Fluphenazine is a phenothiazine antipsychotic that blocks hERG potassium channels and can lengthen the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
この相互作用をわかりやすく説明すると
Fluphenazine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluphenazine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
なぜ起こるのか
Additive blockade of cardiac repolarising potassium currents (hERG)
対処法
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、FluphenazineとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluphenazineのその他の相互作用
Pimozideのその他の相互作用
よくある質問
Can I take Fluphenazine with Pimozide?
MediHelp rates the interaction as contraindicated. Fluphenazine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluphenazine is a phenothiazine antipsychotic that blocks hERG potassium channels and can lengthen the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Fluphenazine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
