相互作用
Arsenic trioxide + Fluphenazine
重症度: 併用禁忌
Arsenic trioxide and Fluphenazine: contraindicated interaction.
最終更新日
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概要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Fluphenazine belongs to Central Nervous System.
なぜ起こるのか
Additive pharmacodynamic QT prolongation.
対処法
Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとFluphenazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluphenazineのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Fluphenazine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
How serious is the interaction between Arsenic trioxide and Fluphenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Fluphenazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
