相互作用
Ganciclovir + Imipenem / cilastatin
重症度: 重大
Ganciclovir and Imipenem / cilastatin: major interaction.
最終更新日
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概要
Generalized seizures have been reported in patients given ganciclovir together with imipenem/cilastatin. Imipenem can lower the seizure threshold, and the combination appears to add to that risk.
この相互作用をわかりやすく説明すると
Ganciclovir and Imipenem / cilastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Probable additive lowering of the seizure threshold; the exact mechanism is not established.
対処法
Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If it must be used, adjust doses for renal function and monitor for neurological symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GanciclovirとImipenem / cilastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ganciclovirのその他の相互作用
よくある質問
Can I take Ganciclovir with Imipenem / cilastatin?
MediHelp rates the interaction as major. Ganciclovir and Imipenem / cilastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Generalized seizures have been reported in patients given ganciclovir together with imipenem/cilastatin. Imipenem can lower the seizure threshold, and the combination appears to add to that risk.
How serious is the interaction between Ganciclovir and Imipenem / cilastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If it must be used, adjust doses for renal function and monitor for neurological symptoms.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
