相互作用
Gliclazide + Mecasermin
重症度: 重大
Gliclazide and Mecasermin: major interaction.
最終更新日
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概要
Mecasermin is recombinant IGF-1 and itself causes hypoglycemia. Combined with a sulfonylurea, the glucose-lowering effect is additive and severe hypoglycemia may occur.
この相互作用をわかりやすく説明すると
Gliclazide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gliclazide belongs to Endocrine; Mecasermin belongs to Endocrine.
なぜ起こるのか
Additive pharmacodynamic hypoglycemic effects, as IGF-1 has insulin-like activity and gliclazide stimulates insulin secretion.
対処法
Monitor blood glucose closely and consider reducing the gliclazide dose. Give mecasermin with or shortly after a meal and teach the patient to recognize and treat hypoglycemia.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GliclazideとMecaserminの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gliclazideのその他の相互作用
Mecaserminのその他の相互作用
よくある質問
Can I take Gliclazide with Mecasermin?
MediHelp rates the interaction as major. Gliclazide and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and itself causes hypoglycemia. Combined with a sulfonylurea, the glucose-lowering effect is additive and severe hypoglycemia may occur.
How serious is the interaction between Gliclazide and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the gliclazide dose. Give mecasermin with or shortly after a meal and teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
