相互作用
Ciprofloxacin + Gliclazide
重症度: 重大
Ciprofloxacin and Gliclazide: major interaction.
最終更新日
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概要
Fluoroquinolones such as ciprofloxacin can cause both severe hypoglycemia and hyperglycemia, especially in patients taking sulfonylureas. Older patients and those with renal impairment are at greatest risk.
この相互作用をわかりやすく説明すると
Ciprofloxacin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Gliclazide belongs to Endocrine.
なぜ起こるのか
Fluoroquinolones alter pancreatic beta-cell insulin release, adding to sulfonylurea-induced insulin secretion; CYP2C9 inhibition may also contribute.
対処法
Monitor blood glucose closely during the antibiotic course and warn the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant glucose disturbance occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CiprofloxacinとGliclazideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gliclazideのその他の相互作用
Ciprofloxacinのその他の相互作用
よくある質問
Can I take Ciprofloxacin with Gliclazide?
MediHelp rates the interaction as major. Ciprofloxacin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones such as ciprofloxacin can cause both severe hypoglycemia and hyperglycemia, especially in patients taking sulfonylureas. Older patients and those with renal impairment are at greatest risk.
How serious is the interaction between Ciprofloxacin and Gliclazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and warn the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant glucose disturbance occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Clarithromycin, Disopyramide, Fluconazole. The full list is on the Gliclazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
